Lorenzo di Medici and Clarice Orsini had ten children, including their oldest son, Piero de Lorenzo de Medici, called "the Unfortunate," because of the events he allowed to unfold after his father's death.
But that is skipping ahead of the date, 1488, when Piero married Alfonsina Orsini, who was 16 at the time, and the daughter of Roberto Orsini, Conte Tagliacozzo, and Catherine San Severino. While Piero may be called "the Unfortunate," it was a fortunate marriage for the Medici family (and the city of Florence) because decades later Alfonsina would serve as Regent.
The portrait above, by Botticelli, is currently in the inventory of the Palazzo Pitti. To my knowledge it has not been on display in recent years. But just as there is renewed interest in Anna Luisa de Medici (and that's skipping centuries ahead) currently, perhaps there will come a time when some curator decides to do an exhibition on the Medici wives.
